IgM Nephropathy

IgM Nephropathy also known as immunoglobulin M, M antibodies is a type of mesangial proliferativeglomerulonephritis. It is the inflammation of the renal glomerulus due to the abnormal accumulation of the igm antibody in the mesangium cover of the glomerular capillary. It is a type of glomerulonephritis which appears to be caused by an abnormal immune response. This disorder often manifests as nephropathy syndrome.

Symptoms of IgM nephropathy

Some of the common symptoms of IgM nephropathy can be listed as below:

  • Swelling
  • Dark urine
  • Weight gain
  • Hypertension
  • Anorexia
  • Blood in urine

Afflicting conditions

Some of the conditions which may afflict the person with IgM nephropathy are:

  • IgM deficiency
  • Dysgamma globulinemia
  • Use of immunosuppressive drugs

About IgM nephropathy

IgM nephropathy (IgMN) is an idiopathic clinicopathologic term causing nephrotic syndrome and is characterized by discoloration of the mesangium by antiserum to IgM on immunofluorescence. Glomeruli reveal diverse grade of mesangial hypercellularity or at times no changes by light microscopy. The etiology of the depositions and association to minimal change disease (MCD) remain unclear. Some researchers consider IgM nephropathy and MCD clinically identical diseases.

IgM is a form of antibody, substances that fight harmful pathogens and microorganisms which can invade the body and cause problems to the health, like infections and others. IgM antibodies are found in b-lymphocytes and are the first antibodies secreted to fight infection after the body is exposed to any harmful pathogen.

Treatment for IgM nephropathy

The treatment for IgM nephropathy is more or less similar to that of IgA nephropathy. Hormone medicine and immune-suppressive agents are generally used. However, this medication can only control the symptoms, but fails to cure the disease. Moreover, hormone medicine has various side effects. While suppressing the atypical immune reaction, it also affects the normal immunity. Thus, the patient will become weak and it increases the possibility for the disease to recur.

Some of the authentic Chinese herbal medications are known to be most effective for the IgM nephropathy and its symptoms. These medicines are:

  • Micro Chinese medicine

Osmo-therapy in Kidney Disease Hospital has excellent effect on removing urine protein and plays a role in recovering renal function and increasing the strength of the immune system of the patient. As long as the patient continues with the treatment as per his own disease and physical condition, this will be beneficial for the recovery of the disease.

The medicine directly reaches the kidneys through skin of the back with the action of the osmo-scope. It can expand the blood vessels and allow the complete blood circulation thus improving the state of kidney ischemia and anoxia. The blood circulation in the kidneys will be increased after the treatment, so the immune complex accumulated on the glomerular basement membrane will be discharged out of body with the blood flow in the urine. This Chinese medicine also provides nutrient material required for kidney repair and aid repair the damaged basement membrane and recover the reduced renal function. Once the disease is cured form the root it may not easily recur.

Prognosis of IgM nephropathy

The connection between rising proteinuria and a worse prognosis of IgM nephropathy is probably in part a reflection of proteinuria being an indicator for the severity of glomerular disease. The rate of development is very low among patients excreting protein less than 500 mg in a day and is fastest among those excreting more than 3.0 to 3.5 g in a day.


A low antigen diet involves avoiding gluten, dairy products, eggs, and most of the meats. The rationale for this routine is that dietary macromolecules can be responsible for activating the mucosal IgM system. Besides, repeat renal biopsy showed major reductions in mesangial IgA and balance deposition and mesangial cellularity.

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